RapamycinFungusV1, Main, Exploration, bibRecord, 000A04

Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation.

Identifieur interne : 000A04 ( Main/Exploration ); précédent : 000A03; suivant : 000A05

Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation.

Auteurs : Niloufar Safinia [Royaume-Uni] ; Trishan Vaikunthanathan [Royaume-Uni] ; Henrieta Fraser [Royaume-Uni] ; Sarah Thirkell [Royaume-Uni] ; Katie Lowe [Royaume-Uni] ; Laura Blackmore [Royaume-Uni] ; Gavin Whitehouse [Royaume-Uni] ; Marc Martinez-Llordella [Royaume-Uni] ; Wayel Jassem [Royaume-Uni] ; Alberto Sanchez-Fueyo [Royaume-Uni] ; Robert I. Lechler [Royaume-Uni] ; Giovanna Lombardi [Royaume-Uni]

Source :

Oncotarget [ 1949-2553 ] ; 2016.

RBID : pubmed:26788992

Descripteurs français

KwdFr :
- Cellules Th17 (cytologie), Cellules Th17 (effets des médicaments et des substances chimiques), Cellules Th17 (immunologie), Cellules cultivées (MeSH), Cirrhose du foie (immunologie), Cirrhose du foie (thérapie), Cytométrie en flux (MeSH), Humains (MeSH), Immunosuppresseurs (usage thérapeutique), Immunothérapie (MeSH), Lymphocytes T (cytologie), Lymphocytes T (effets des médicaments et des substances chimiques), Lymphocytes T (immunologie), Lymphocytes T régulateurs (cytologie), Lymphocytes T régulateurs (effets des médicaments et des substances chimiques), Lymphocytes T régulateurs (immunologie), Test ELISA (MeSH), Tolérance immunitaire (effets des médicaments et des substances chimiques), Tolérance immunitaire (immunologie), Transplantation hépatique (MeSH), Troubles liés à l'alcool (immunologie), Troubles liés à l'alcool (thérapie), Études de suivi (MeSH), Études prospectives (MeSH).
MESH :
- cytologie : Cellules Th17, Lymphocytes T, Lymphocytes T régulateurs.
- effets des médicaments et des substances chimiques : Cellules Th17, Lymphocytes T, Lymphocytes T régulateurs, Tolérance immunitaire.
- immunologie : Cellules Th17, Cirrhose du foie, Lymphocytes T, Lymphocytes T régulateurs, Tolérance immunitaire, Troubles liés à l'alcool.
- thérapie : Cirrhose du foie, Troubles liés à l'alcool.
- usage thérapeutique : Immunosuppresseurs.
- Cellules cultivées, Cytométrie en flux, Humains, Immunothérapie, Test ELISA, Transplantation hépatique, Études de suivi, Études prospectives.

English descriptors

KwdEn :
- Alcohol-Related Disorders (immunology), Alcohol-Related Disorders (therapy), Cells, Cultured (MeSH), Enzyme-Linked Immunosorbent Assay (MeSH), Flow Cytometry (MeSH), Follow-Up Studies (MeSH), Humans (MeSH), Immune Tolerance (drug effects), Immune Tolerance (immunology), Immunosuppressive Agents (therapeutic use), Immunotherapy (MeSH), Liver Cirrhosis (immunology), Liver Cirrhosis (therapy), Liver Transplantation (MeSH), Prospective Studies (MeSH), T-Lymphocytes (cytology), T-Lymphocytes (drug effects), T-Lymphocytes (immunology), T-Lymphocytes, Regulatory (cytology), T-Lymphocytes, Regulatory (drug effects), T-Lymphocytes, Regulatory (immunology), Th17 Cells (cytology), Th17 Cells (drug effects), Th17 Cells (immunology).
MESH :
- chemical , therapeutic use : Immunosuppressive Agents.
- cytology : T-Lymphocytes, T-Lymphocytes, Regulatory, Th17 Cells.
- drug effects : Immune Tolerance, T-Lymphocytes, T-Lymphocytes, Regulatory, Th17 Cells.
- immunology : Alcohol-Related Disorders, Immune Tolerance, Liver Cirrhosis, T-Lymphocytes, T-Lymphocytes, Regulatory, Th17 Cells.
- therapy : Alcohol-Related Disorders, Liver Cirrhosis.
- Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Follow-Up Studies, Humans, Immunotherapy, Liver Transplantation, Prospective Studies.

Abstract

Strategies to prevent organ transplant rejection whilst minimizing long-term immunosuppression are currently under intense investigation with regulatory T cells (Tregs) nearing clinical application. The clinical trial, ThRIL, recently commenced at King's College London, proposes to use Treg cell therapy to induce tolerance in liver transplant recipients, the success of which has the potential to revolutionize the management of these patients and enable a future of drug-free transplants. This is the first report of the manufacture of clinical grade Tregs from prospective liver transplant recipients via a CliniMACS-based GMP isolation technique and expanded using anti-CD3/CD28 beads, IL-2 and rapamycin. We report the enrichment of a pure, stable population of Tregs (>95% CD4(+)CD25(+)FOXP3(+)), reaching adequate numbers for their clinical application. Our protocol proved successful in, influencing the expansion of superior functional Tregs, as compared to freshly isolated cells, whilst also preventing their conversion to Th17 cells under pro-inflammatory conditions. We conclude with the manufacture of the final Treg product in the clinical research facility (CRF), a prerequisite for the clinical application of these cells. The data presented in this manuscript together with the much-anticipated clinical results from ThRIL, will undoubtedly inform the improved management of the liver transplant recipient.

DOI: 10.18632/oncotarget.6927
PubMed: 26788992
PubMed Central: PMC4884938

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000B19
to stream Main, to step Curation: 000B19

Le document en format XML

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<author><name sortKey="Martinez Llordella, Marc" sort="Martinez Llordella, Marc" uniqKey="Martinez Llordella M" first="Marc" last="Martinez-Llordella">Marc Martinez-Llordella</name>
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<author><name sortKey="Sanchez Fueyo, Alberto" sort="Sanchez Fueyo, Alberto" uniqKey="Sanchez Fueyo A" first="Alberto" last="Sanchez-Fueyo">Alberto Sanchez-Fueyo</name>
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<region type="région" nuts="1">Grand Londres</region>
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<region type="région" nuts="1">Grand Londres</region>
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<author><name sortKey="Lombardi, Giovanna" sort="Lombardi, Giovanna" uniqKey="Lombardi G" first="Giovanna" last="Lombardi">Giovanna Lombardi</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation.</title>
<author><name sortKey="Safinia, Niloufar" sort="Safinia, Niloufar" uniqKey="Safinia N" first="Niloufar" last="Safinia">Niloufar Safinia</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
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<author><name sortKey="Vaikunthanathan, Trishan" sort="Vaikunthanathan, Trishan" uniqKey="Vaikunthanathan T" first="Trishan" last="Vaikunthanathan">Trishan Vaikunthanathan</name>
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<author><name sortKey="Fraser, Henrieta" sort="Fraser, Henrieta" uniqKey="Fraser H" first="Henrieta" last="Fraser">Henrieta Fraser</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
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<author><name sortKey="Thirkell, Sarah" sort="Thirkell, Sarah" uniqKey="Thirkell S" first="Sarah" last="Thirkell">Sarah Thirkell</name>
<affiliation wicri:level="3"><nlm:affiliation>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
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</author>
<author><name sortKey="Lowe, Katie" sort="Lowe, Katie" uniqKey="Lowe K" first="Katie" last="Lowe">Katie Lowe</name>
<affiliation wicri:level="3"><nlm:affiliation>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blackmore, Laura" sort="Blackmore, Laura" uniqKey="Blackmore L" first="Laura" last="Blackmore">Laura Blackmore</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Liver Studies, King's College Hospital, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Liver Studies, King's College Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Whitehouse, Gavin" sort="Whitehouse, Gavin" uniqKey="Whitehouse G" first="Gavin" last="Whitehouse">Gavin Whitehouse</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Liver Studies, King's College Hospital, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Liver Studies, King's College Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martinez Llordella, Marc" sort="Martinez Llordella, Marc" uniqKey="Martinez Llordella M" first="Marc" last="Martinez-Llordella">Marc Martinez-Llordella</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Liver Studies, King's College Hospital, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Liver Studies, King's College Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jassem, Wayel" sort="Jassem, Wayel" uniqKey="Jassem W" first="Wayel" last="Jassem">Wayel Jassem</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Liver Studies, King's College Hospital, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Liver Studies, King's College Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sanchez Fueyo, Alberto" sort="Sanchez Fueyo, Alberto" uniqKey="Sanchez Fueyo A" first="Alberto" last="Sanchez-Fueyo">Alberto Sanchez-Fueyo</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Liver Studies, King's College Hospital, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Liver Studies, King's College Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lechler, Robert I" sort="Lechler, Robert I" uniqKey="Lechler R" first="Robert I" last="Lechler">Robert I. Lechler</name>
<affiliation wicri:level="3"><nlm:affiliation>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lombardi, Giovanna" sort="Lombardi, Giovanna" uniqKey="Lombardi G" first="Giovanna" last="Lombardi">Giovanna Lombardi</name>
<affiliation wicri:level="3"><nlm:affiliation>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Oncotarget</title>
<idno type="eISSN">1949-2553</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alcohol-Related Disorders (immunology)</term>
<term>Alcohol-Related Disorders (therapy)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Enzyme-Linked Immunosorbent Assay (MeSH)</term>
<term>Flow Cytometry (MeSH)</term>
<term>Follow-Up Studies (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immune Tolerance (drug effects)</term>
<term>Immune Tolerance (immunology)</term>
<term>Immunosuppressive Agents (therapeutic use)</term>
<term>Immunotherapy (MeSH)</term>
<term>Liver Cirrhosis (immunology)</term>
<term>Liver Cirrhosis (therapy)</term>
<term>Liver Transplantation (MeSH)</term>
<term>Prospective Studies (MeSH)</term>
<term>T-Lymphocytes (cytology)</term>
<term>T-Lymphocytes (drug effects)</term>
<term>T-Lymphocytes (immunology)</term>
<term>T-Lymphocytes, Regulatory (cytology)</term>
<term>T-Lymphocytes, Regulatory (drug effects)</term>
<term>T-Lymphocytes, Regulatory (immunology)</term>
<term>Th17 Cells (cytology)</term>
<term>Th17 Cells (drug effects)</term>
<term>Th17 Cells (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Cellules Th17 (cytologie)</term>
<term>Cellules Th17 (effets des médicaments et des substances chimiques)</term>
<term>Cellules Th17 (immunologie)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Cirrhose du foie (immunologie)</term>
<term>Cirrhose du foie (thérapie)</term>
<term>Cytométrie en flux (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Immunosuppresseurs (usage thérapeutique)</term>
<term>Immunothérapie (MeSH)</term>
<term>Lymphocytes T (cytologie)</term>
<term>Lymphocytes T (effets des médicaments et des substances chimiques)</term>
<term>Lymphocytes T (immunologie)</term>
<term>Lymphocytes T régulateurs (cytologie)</term>
<term>Lymphocytes T régulateurs (effets des médicaments et des substances chimiques)</term>
<term>Lymphocytes T régulateurs (immunologie)</term>
<term>Test ELISA (MeSH)</term>
<term>Tolérance immunitaire (effets des médicaments et des substances chimiques)</term>
<term>Tolérance immunitaire (immunologie)</term>
<term>Transplantation hépatique (MeSH)</term>
<term>Troubles liés à l'alcool (immunologie)</term>
<term>Troubles liés à l'alcool (thérapie)</term>
<term>Études de suivi (MeSH)</term>
<term>Études prospectives (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Immunosuppressive Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules Th17</term>
<term>Lymphocytes T</term>
<term>Lymphocytes T régulateurs</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>T-Lymphocytes</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Th17 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immune Tolerance</term>
<term>T-Lymphocytes</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Th17 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Cellules Th17</term>
<term>Lymphocytes T</term>
<term>Lymphocytes T régulateurs</term>
<term>Tolérance immunitaire</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules Th17</term>
<term>Cirrhose du foie</term>
<term>Lymphocytes T</term>
<term>Lymphocytes T régulateurs</term>
<term>Tolérance immunitaire</term>
<term>Troubles liés à l'alcool</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Alcohol-Related Disorders</term>
<term>Immune Tolerance</term>
<term>Liver Cirrhosis</term>
<term>T-Lymphocytes</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Th17 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Alcohol-Related Disorders</term>
<term>Liver Cirrhosis</term>
</keywords>
<keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Cirrhose du foie</term>
<term>Troubles liés à l'alcool</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Immunosuppresseurs</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cells, Cultured</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Flow Cytometry</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Immunotherapy</term>
<term>Liver Transplantation</term>
<term>Prospective Studies</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Cellules cultivées</term>
<term>Cytométrie en flux</term>
<term>Humains</term>
<term>Immunothérapie</term>
<term>Test ELISA</term>
<term>Transplantation hépatique</term>
<term>Études de suivi</term>
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<front><div type="abstract" xml:lang="en">Strategies to prevent organ transplant rejection whilst minimizing long-term immunosuppression are currently under intense investigation with regulatory T cells (Tregs) nearing clinical application. The clinical trial, ThRIL, recently commenced at King's College London, proposes to use Treg cell therapy to induce tolerance in liver transplant recipients, the success of which has the potential to revolutionize the management of these patients and enable a future of drug-free transplants. This is the first report of the manufacture of clinical grade Tregs from prospective liver transplant recipients via a CliniMACS-based GMP isolation technique and expanded using anti-CD3/CD28 beads, IL-2 and rapamycin. We report the enrichment of a pure, stable population of Tregs (>95% CD4(+)CD25(+)FOXP3(+)), reaching adequate numbers for their clinical application. Our protocol proved successful in, influencing the expansion of superior functional Tregs, as compared to freshly isolated cells, whilst also preventing their conversion to Th17 cells under pro-inflammatory conditions. We conclude with the manufacture of the final Treg product in the clinical research facility (CRF), a prerequisite for the clinical application of these cells. The data presented in this manuscript together with the much-anticipated clinical results from ThRIL, will undoubtedly inform the improved management of the liver transplant recipient.</div>
</front>
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<DateCompleted><Year>2016</Year>
<Month>12</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>10</Month>
<Day>08</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1949-2553</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>7</Volume>
<Issue>7</Issue>
<PubDate><Year>2016</Year>
<Month>Feb</Month>
<Day>16</Day>
</PubDate>
</JournalIssue>
<Title>Oncotarget</Title>
<ISOAbbreviation>Oncotarget</ISOAbbreviation>
</Journal>
<ArticleTitle>Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation.</ArticleTitle>
<Pagination><MedlinePgn>7563-77</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.18632/oncotarget.6927</ELocationID>
<Abstract><AbstractText>Strategies to prevent organ transplant rejection whilst minimizing long-term immunosuppression are currently under intense investigation with regulatory T cells (Tregs) nearing clinical application. The clinical trial, ThRIL, recently commenced at King's College London, proposes to use Treg cell therapy to induce tolerance in liver transplant recipients, the success of which has the potential to revolutionize the management of these patients and enable a future of drug-free transplants. This is the first report of the manufacture of clinical grade Tregs from prospective liver transplant recipients via a CliniMACS-based GMP isolation technique and expanded using anti-CD3/CD28 beads, IL-2 and rapamycin. We report the enrichment of a pure, stable population of Tregs (>95% CD4(+)CD25(+)FOXP3(+)), reaching adequate numbers for their clinical application. Our protocol proved successful in, influencing the expansion of superior functional Tregs, as compared to freshly isolated cells, whilst also preventing their conversion to Th17 cells under pro-inflammatory conditions. We conclude with the manufacture of the final Treg product in the clinical research facility (CRF), a prerequisite for the clinical application of these cells. The data presented in this manuscript together with the much-anticipated clinical results from ThRIL, will undoubtedly inform the improved management of the liver transplant recipient.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Safinia</LastName>
<ForeName>Niloufar</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vaikunthanathan</LastName>
<ForeName>Trishan</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fraser</LastName>
<ForeName>Henrieta</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thirkell</LastName>
<ForeName>Sarah</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lowe</LastName>
<ForeName>Katie</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blackmore</LastName>
<ForeName>Laura</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Institute of Liver Studies, King's College Hospital, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Whitehouse</LastName>
<ForeName>Gavin</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Institute of Liver Studies, King's College Hospital, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Martinez-Llordella</LastName>
<ForeName>Marc</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Institute of Liver Studies, King's College Hospital, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jassem</LastName>
<ForeName>Wayel</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Institute of Liver Studies, King's College Hospital, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sanchez-Fueyo</LastName>
<ForeName>Alberto</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Institute of Liver Studies, King's College Hospital, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lechler</LastName>
<ForeName>Robert I</ForeName>
<Initials>RI</Initials>
<AffiliationInfo><Affiliation>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lombardi</LastName>
<ForeName>Giovanna</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>RG/13/12/30395</GrantID>
<Agency>British Heart Foundation</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>G1002000</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><Agency>Department of Health</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>MR/J006742/1</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>MR/L022699/1</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>MR/K025538/1</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>MR/L008890/1</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
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<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
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<MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName>
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<MeshHeading><DescriptorName UI="D005434" MajorTopicYN="N">Flow Cytometry</DescriptorName>
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<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
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<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
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<MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
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<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
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<QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
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<Keyword MajorTopicYN="N">Immunity</Keyword>
<Keyword MajorTopicYN="N">Immunology and Microbiology Section</Keyword>
<Keyword MajorTopicYN="N">immunosuppression</Keyword>
<Keyword MajorTopicYN="N">immunotherapy</Keyword>
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<name sortKey="Fraser, Henrieta" sort="Fraser, Henrieta" uniqKey="Fraser H" first="Henrieta" last="Fraser">Henrieta Fraser</name>
<name sortKey="Jassem, Wayel" sort="Jassem, Wayel" uniqKey="Jassem W" first="Wayel" last="Jassem">Wayel Jassem</name>
<name sortKey="Lechler, Robert I" sort="Lechler, Robert I" uniqKey="Lechler R" first="Robert I" last="Lechler">Robert I. Lechler</name>
<name sortKey="Lombardi, Giovanna" sort="Lombardi, Giovanna" uniqKey="Lombardi G" first="Giovanna" last="Lombardi">Giovanna Lombardi</name>
<name sortKey="Lowe, Katie" sort="Lowe, Katie" uniqKey="Lowe K" first="Katie" last="Lowe">Katie Lowe</name>
<name sortKey="Martinez Llordella, Marc" sort="Martinez Llordella, Marc" uniqKey="Martinez Llordella M" first="Marc" last="Martinez-Llordella">Marc Martinez-Llordella</name>
<name sortKey="Sanchez Fueyo, Alberto" sort="Sanchez Fueyo, Alberto" uniqKey="Sanchez Fueyo A" first="Alberto" last="Sanchez-Fueyo">Alberto Sanchez-Fueyo</name>
<name sortKey="Thirkell, Sarah" sort="Thirkell, Sarah" uniqKey="Thirkell S" first="Sarah" last="Thirkell">Sarah Thirkell</name>
<name sortKey="Vaikunthanathan, Trishan" sort="Vaikunthanathan, Trishan" uniqKey="Vaikunthanathan T" first="Trishan" last="Vaikunthanathan">Trishan Vaikunthanathan</name>
<name sortKey="Whitehouse, Gavin" sort="Whitehouse, Gavin" uniqKey="Whitehouse G" first="Gavin" last="Whitehouse">Gavin Whitehouse</name>
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{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:26788992
   |texte=   Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation.
}}

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	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation.

Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation.

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